This is probably the most comfortable mouse I have ever used, and it costs lest than a fifth of the closest alternative I tried! I don't suffer from any wrist issues, so I can't comment on whether this mouse helps alleviate them - I simply find vertical grip to be more natural and comfortable. Unfortunately, there aren't that many options on the market that I like. Considering the low price of Ugreen, I thought it wouldn't hurt giving it a try. And... wow! I'm glad I did! Here are just some of the benefits: - The mouse is very comfortable and feels very natural to hold. - You can connect it simultaneously to 3 different devices (two BT connections, and one 2.4G through a dongle). - It's totally quiet - the clicks are "soft" like in some much more expensive productivity-focused mice, but they are also very tactile and well-defined. - Works totally fine on every surface I tried: white desk, wooden surfaces, black mouse pad - no issues whatsoever. - DPI settings are easy to adjust on the fly, and you don't have to install any third-party software for it. - It's cheap! Not everything is perfect, of course, but the criticism I have for this mouse is pretty minor: - The build quality is a little plasticky. It doesn't feel too cheap, but don't expect anything exceptional here. I do, however, prefer hard plastic over "rubberized" surfaces of more expensive products simply because it doesn't act like a dirt and grease magnet. So I would even say I like the plastic build. - The polling rate for this mouse is not advertised (at least I failed to find it), but my testing showed around 125Hz. On one hand, it's not a lot if you are coming from "gaming" mice, but then again... MX Master 4 that costs literally 10 times as much still has the same 125Hz polling rate, so there's that. 120Hz is still perfectly fine for non-competitive gaming and more than enough for productivity work. - One of the feet on my sample was glued crooked, so one of the corners was catching slightly on the mousepad. Not a huge issue, and easily fixable too. Overall - it's a phenomenal product. Highly recommended and worth every cent.